α7 Nicotinic Acetylcholine Receptor-Specific Antibody Induces Inflammation and Amyloid β(42) Accumulation in the Mouse Brain to Impair Memory

Nicotinic acetylcholine receptors (nAChRs) expressed in the brain are involved in regulating cognitive functions, as well as inflammatory reactions. Their density is decreased upon Alzheimer disease accompanied by accumulation of β-amyloid (Aβ(42)), memory deficit and neuroinflammation. Previously w...

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Publicado en:PLoS One
Autores principales: Lykhmus, Olena, Voytenko, Larysa, Koval, Lyudmyla, Mykhalskiy, Sergiy, Kholin, Victor, Peschana, Kateryna, Zouridakis, Marios, Tzartos, Socrates, Komisarenko, Sergiy, Skok, Maryna
Formato: Artigo
Lenguaje:Inglês
Publicado: Public Library of Science 2015
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376778/
https://ncbi.nlm.nih.gov/pubmed/25816313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122706
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