α7 Nicotinic Acetylcholine Receptor-Specific Antibody Induces Inflammation and Amyloid β(42) Accumulation in the Mouse Brain to Impair Memory

Nicotinic acetylcholine receptors (nAChRs) expressed in the brain are involved in regulating cognitive functions, as well as inflammatory reactions. Their density is decreased upon Alzheimer disease accompanied by accumulation of β-amyloid (Aβ(42)), memory deficit and neuroinflammation. Previously w...

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Publicat a:PLoS One
Autors principals: Lykhmus, Olena, Voytenko, Larysa, Koval, Lyudmyla, Mykhalskiy, Sergiy, Kholin, Victor, Peschana, Kateryna, Zouridakis, Marios, Tzartos, Socrates, Komisarenko, Sergiy, Skok, Maryna
Format: Artigo
Idioma:Inglês
Publicat: Public Library of Science 2015
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376778/
https://ncbi.nlm.nih.gov/pubmed/25816313
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0122706
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