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Allostery Mediates Ligand Binding to WWOX Tumor Suppressor via a Conformational Switch
While being devoid of the ability to recognize ligands itself, the WW2 domain is believed to aid ligand binding to WW1 domain in the context of WW1-WW2 tandem module of WWOX tumor suppressor. In an effort to test the generality of this hypothesis, we have undertaken here a detailed biophysical analy...
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| Veröffentlicht in: | J Mol Recognit |
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| Hauptverfasser: | , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376589/ https://ncbi.nlm.nih.gov/pubmed/25703206 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jmr.2419 |
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