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Molecular Origin of the Binding of WWOX Tumor Suppressor to ErbB4 Receptor Tyrosine Kinase

The ability of WWOX tumor suppressor to physically associate with the intracellular domain (ICD) of ErbB4 receptor tyrosine kinase is believed to play a central role in down-regulating the transcriptional function of the latter. Herein, using various biophysical methods, we show that while the WW1 d...

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Détails bibliographiques
Auteurs principaux: Schuchardt, Brett J., Bhat, Vikas, Mikles, David C., McDonald, Caleb B., Sudol, Marius, Farooq, Amjad
Format: Artigo
Langue:Inglês
Publié: 2013
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3906126/
https://ncbi.nlm.nih.gov/pubmed/24308844
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi400987k
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