Ligand Binding to WW Tandem Domains of YAP2 Transcriptional Regulator Is Under Negative Cooperativity

YAP2 transcriptional regulator drives a multitude of cellular processes, including the newly discovered Hippo tumor suppressor pathway, by virtue of the ability of its WW domains to bind and recruit PPXY-containing ligands to specific subcellular compartments. Herein, we employ an array of biophysic...

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Bibliographic Details
Published in:FEBS J
Main Authors: Schuchardt, Brett J., Mikles, David C., Hoang, Lawrence M., Bhat, Vikas, McDonald, Caleb B., Sudol, Marius, Farooq, Amjad
Format: Artigo
Language:Inglês
Published: 2014
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4262544/
https://ncbi.nlm.nih.gov/pubmed/25283809
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.13095
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