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Notum deacylates Wnts to suppress signalling activity
Signalling by Wnts is finely balanced to ensure normal development and tissue homeostasis while avoiding diseases such as cancer. This is achieved in part by Notum, a highly conserved secreted feedback antagonist. Notum has been thought to act as a phospholipase, shedding glypicans and associated Wn...
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| Vydáno v: | Nature |
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| Hlavní autoři: | , , , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
2015
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376489/ https://ncbi.nlm.nih.gov/pubmed/25731175 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature14259 |
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