Transmission electron microscopy as an orthogonal method to characterize protein aggregates

Aggregation of protein-based therapeutics is a challenging problem in the biopharmaceutical industry. Of particular concern are implications for product efficacy and clinical safety due to potentially increased immunogenicity of the aggregates. We used transmission electron microscopy (TEM) to chara...

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Библиографические подробности
Опубликовано в: :J Pharm Sci
Главные авторы: Sung, Joyce J., Pardeshi, Neha N., Mulder, Anke M., Mulligan, Sean K., Quispe, Joel, On, Kathy, Carragher, Bridget, Potter, Clinton S., Carpenter, John F., Schneemann, Anette
Формат: Artigo
Язык:Inglês
Опубликовано: 2014
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Article
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376473/
https://ncbi.nlm.nih.gov/pubmed/25231267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24157
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