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Transmission electron microscopy as an orthogonal method to characterize protein aggregates

Aggregation of protein-based therapeutics is a challenging problem in the biopharmaceutical industry. Of particular concern are implications for product efficacy and clinical safety due to potentially increased immunogenicity of the aggregates. We used transmission electron microscopy (TEM) to chara...

Täydet tiedot

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Bibliografiset tiedot
Julkaisussa:J Pharm Sci
Päätekijät: Sung, Joyce J., Pardeshi, Neha N., Mulder, Anke M., Mulligan, Sean K., Quispe, Joel, On, Kathy, Carragher, Bridget, Potter, Clinton S., Carpenter, John F., Schneemann, Anette
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2014
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376473/
https://ncbi.nlm.nih.gov/pubmed/25231267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24157
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