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Transmission electron microscopy as an orthogonal method to characterize protein aggregates
Aggregation of protein-based therapeutics is a challenging problem in the biopharmaceutical industry. Of particular concern are implications for product efficacy and clinical safety due to potentially increased immunogenicity of the aggregates. We used transmission electron microscopy (TEM) to chara...
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| Publicado no: | J Pharm Sci |
|---|---|
| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4376473/ https://ncbi.nlm.nih.gov/pubmed/25231267 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24157 |
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