Transmission electron microscopy as an orthogonal method to characterize protein aggregates

Aggregation of protein-based therapeutics is a challenging problem in the biopharmaceutical industry. Of particular concern are implications for product efficacy and clinical safety due to potentially increased immunogenicity of the aggregates. We used transmission electron microscopy (TEM) to chara...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Pharm Sci
Main Authors: Sung, Joyce J., Pardeshi, Neha N., Mulder, Anke M., Mulligan, Sean K., Quispe, Joel, On, Kathy, Carragher, Bridget, Potter, Clinton S., Carpenter, John F., Schneemann, Anette
Format: Artigo
Jezik:Inglês
Izdano: 2014
Teme:
Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376473/
https://ncbi.nlm.nih.gov/pubmed/25231267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24157
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