CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK–779

BACKGROUND AND PURPOSE: The chemokine receptor CXCR3 is implicated in a variety of clinically important diseases, notably rheumatoid arthritis and atherosclerosis. Consequently, antagonists of CXCR3 are of therapeutic interest. In this study, we set out to characterize binding sites of the specific...

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Bibliographische Detailangaben
Veröffentlicht in:Br J Pharmacol
Hauptverfasser: Nedjai, Belinda, Viney, Jonathan M, Li, Hubert, Hull, Caroline, Anderson, Caroline A, Horie, Tomoki, Horuk, Richard, Vaidehi, Nagarajan, Pease, James E
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
Schlagworte:
Research Papers
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376459/
https://ncbi.nlm.nih.gov/pubmed/25425280
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bph.13027
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