Targeting chemokine receptors in disease – a case study of CCR4

Por Solari, Roberto, Pease, James E.
Publicado no Eur J Pharmacol (2015)

The attraction of chemokines as a target for specific anti-inflammatory therapy

Por Pease, James E, Williams, Timothy J
Publicado em 2006

The use of membrane translocating peptides to identify sites of interaction between the C5a receptor and downstream effector proteins

Por Auger, Graham A, Smith, Brenda M, Pease, James E, Barker, Michael D
Publicado em 2004

SMALL MOLECULE RECEPTOR AGONISTS AND ANTAGONISTS OF CCR3 PROVIDE INSIGHT INTO MECHANISMS OF CHEMOKINE RECEPTOR ACTIVATION

Por Wise, Emma L., Duchesnes, Cécile, da Fonseca, Paula C.A., Allen, Rodger A., Williams, Timothy J., Pease, James E.
Publicado em 2007

A distinct subset of human NK cells expressing HLA-DR expand in response to IL-2 and can aid immune responses to BCG

Por Evans, J Henry, Horowitz, Amir, Mehrabi, Maryam, Wise, Emma L, Pease, James E, Riley, Eleanor M, Davis, Daniel M
Publicado em 2011

IRF5 controls both acute and chronic inflammation

Por Weiss, Miriam, Byrne, Adam J., Blazek, Katrina, Saliba, David G., Pease, James E., Perocheau, Dany, Feldmann, Marc, Udalova, Irina A.
Publicado no Proc Natl Acad Sci U S A (2015)

CXCR3 antagonist VUF10085 binds to an intrahelical site distinct from that of the broad spectrum antagonist TAK–779

Por Nedjai, Belinda, Viney, Jonathan M, Li, Hubert, Hull, Caroline, Anderson, Caroline A, Horie, Tomoki, Horuk, Richard, Vaidehi, Nagarajan, Pease, James E
Publicado no Br J Pharmacol (2015)

CCR4 blockade does not inhibit allergic airways inflammation

Por Conroy, Dolores M., Jopling, Louise A., Lloyd, Clare M., Hodge, Martin R., Andrew, David P., Williams, Timothy J., Pease, James E., Sabroe, Ian
Publicado em 2003

THE CHEMOKINE RECEPTOR CXCR3 IS DEGRADED FOLLOWING INTERNALIZATION AND IS REPLENISHED AT THE CELL SURFACE BY DE NOVO SYNTHESIS OF RECEPTOR

Por Meiser, Andrea, Mueller, Anja, Wise, Emma L., McDonagh, Ellen M., Petit, Sarah J., Saran, Namita, Clark, Peter C., Williams, Timothy J., Pease, James E.
Publicado em 2008

IFN-λ resolves inflammation via suppression of neutrophil infiltration and IL-1β production

Por Blazek, Katrina, Eames, Hayley L., Weiss, Miriam, Byrne, Adam J., Perocheau, Dany, Pease, James E., Doyle, Sean, McCann, Fiona, Williams, Richard O., Udalova, Irina A.
Publicado no J Exp Med (2015)

Pulmonary Epithelial Cell-Derived Cytokine TGF-β1 Is a Critical Cofactor for Enhanced Innate Lymphoid Cell Function

Por Denney, Laura, Byrne, Adam J., Shea, Thomas J., Buckley, James S., Pease, James E., Herledan, Gaelle M.F., Walker, Simone A., Gregory, Lisa G., Lloyd, Clare M.
Publicado no Immunity (2015)

Structure and Function of A41, a Vaccinia Virus Chemokine Binding Protein

Por Bahar, Mohammad W, Kenyon, Julia C, Putz, Mike M, Abrescia, Nicola G. A, Pease, James E, Wise, Emma L, Stuart, David I, Smith, Geoffrey L, Grimes, Jonathan M
Publicado em 2008

The Role of the CCL2/CCR2 Axis in Mouse Mast Cell Migration In Vitro and In Vivo

Por Collington, Sarah J., Hallgren, Jenny, Pease, James E., Jones, Tatiana G., Rollins, Barrett J., Westwick, John, Austen, K. Frank, Williams, Timothy J., Gurish, Michael F., Weller, Charlotte L.
Publicado em 2010

DISTINCT CONFORMATIONS OF THE CHEMOKINE RECEPTOR CCR4 WITH IMPLICATIONS FOR ITS TARGETING IN ALLERGY

Por Viney, Jonathan M., Andrew, David P., Phillips, Rhian M., Meiser, Andrea, Patel, Pallavi, Lennartz-Walker, Melissa, Cousins, David J., Barton, Nicholas P., Hall, David A., Pease, James E.
Publicado em 2014

Small molecule chemokine mimetics suggest a molecular basis for the observation that CXCL10 and CXCL11 are allosteric ligands of CXCR3

Por Nedjai, Belinda, Li, Hubert, Stroke, Ilana L, Wise, Emma L, Webb, Maria L, Merritt, J Robert, Henderson, Ian, Klon, Anthony E, Cole, Andrew G, Horuk, Richard, Vaidehi, Nagarajan, Pease, James E
Publicado em 2012

Chemokine and Cytokine Mediated Loss of Regulatory T Cells in Lymph Nodes During Pathogenic Simian Immunodeficiency Virus Infection

Por Qin, Shulin, Sui, Yongjun, Soloff, Adam C., Junecko, Beth A. Fallert, Kirschner, Denise E., Murphey-Corb, Michael A., Watkins, Simon C., Tarwater, Patrick M., Pease, James E., Barratt-Boyes, Simon M., Reinhart, Todd A.
Publicado em 2008

Non-competitive antagonism and inverse agonism as mechanism of action of non-peptidergic antagonists at primate and rodent CXCR3 chemokine receptors

Por Verzijl, Dennis, Storelli, Stefania, Scholten, Danny, Bosch, Leontien, Reinhart, Todd A., Streblow, Daniel N., Tensen, Cornelis P., Fitzsimons, Carlos P., Zaman, Guido J.R., Pease, James E., de Esch, Iwan J.P., Smit, Martine J., Leurs, Rob
Publicado em 2008