DISTINCT CONFORMATIONS OF THE CHEMOKINE RECEPTOR CCR4 WITH IMPLICATIONS FOR ITS TARGETING IN ALLERGY

The chemokine receptor CCR4 is expressed by Th2 and Tregs and directs their migration along gradients of the chemokines CCL17 and CCL22. Both chemokines and receptor are upregulated in allergic disease, making CCR4 a therapeutic target for the treatment of allergy. We set out to assess the mechanism...

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Hlavní autoři: Viney, Jonathan M., Andrew, David P., Phillips, Rhian M., Meiser, Andrea, Patel, Pallavi, Lennartz-Walker, Melissa, Cousins, David J., Barton, Nicholas P., Hall, David A., Pease, James E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2014
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3965571/
https://ncbi.nlm.nih.gov/pubmed/24563252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1300232
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