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HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines
CC chemokine receptor 5 (CCR5) is a receptor for chemokines and the coreceptor for R5 HIV-1 entry into CD4(+) T lymphocytes. Chemokines exert anti–HIV-1 activity in vitro, both by displacing the viral envelope glycoprotein gp120 from binding to CCR5 and by promoting CCR5 endocytosis, suggesting that...
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| Hauptverfasser: | , , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
National Academy of Sciences
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3677469/ https://ncbi.nlm.nih.gov/pubmed/23696662 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222205110 |
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