HIV-1 exploits CCR5 conformational heterogeneity to escape inhibition by chemokines

CC chemokine receptor 5 (CCR5) is a receptor for chemokines and the coreceptor for R5 HIV-1 entry into CD4(+) T lymphocytes. Chemokines exert anti–HIV-1 activity in vitro, both by displacing the viral envelope glycoprotein gp120 from binding to CCR5 and by promoting CCR5 endocytosis, suggesting that...

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Detalhes bibliográficos
Main Authors: Colin, Philippe, Bénureau, Yann, Staropoli, Isabelle, Wang, Yongjin, Gonzalez, Nuria, Alcami, Jose, Hartley, Oliver, Brelot, Anne, Arenzana-Seisdedos, Fernando, Lagane, Bernard
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2013
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3677469/
https://ncbi.nlm.nih.gov/pubmed/23696662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1222205110
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