Comparison of two self-assembled macromolecular prodrug micelles with different conjugate positions of SN38 for enhancing antitumor activity

7-Ethyl-10-hydroxycamptothecin (SN38), an active metabolite of irinotecan (CPT-11), is a remarkably potent antitumor agent. The clinical application of SN38 has been extremely restricted by its insolubility in water. In this study, we successfully synthesized two macromolecular prodrugs of SN38 with...

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Vydáno v:Int J Nanomedicine
Hlavní autoři: Liu, Yi, Piao, Hongyu, Gao, Ying, Xu, Caihong, Tian, Ye, Wang, Lihong, Liu, Jinwen, Tang, Bo, Zou, Meijuan, Cheng, Gang
Médium: Artigo
Jazyk:Inglês
Vydáno: Dove Medical Press 2015
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Original Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376263/
https://ncbi.nlm.nih.gov/pubmed/25848251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S77957
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