Development of Self-Associating SN-38-Conjugated Poly(ethylene oxide)-Poly(ester) Micelles for Colorectal Cancer Therapy

The clinical use of 7-ethyl-10-hydroxy-camptothecin (SN-38), which is the active metabolite of irinotecan, has been hampered because of its practical water-insolubility. In this study, we successfully synthesized two self-associating SN-38-polymer drug conjugates to improve the water-solubility of S...

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Udgivet i:Pharmaceutics
Main Authors: Sadat, Sams M. A., Vakili, Mohammad Reza, Paiva, Igor M., Weinfeld, Michael, Lavasanifar, Afsaneh
Format: Artigo
Sprog:Inglês
Udgivet: MDPI 2020
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7694018/
https://ncbi.nlm.nih.gov/pubmed/33138058
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/pharmaceutics12111033
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