Phase I Dose-Escalation Study of EZN-2208 (PEG-SN38), a Novel Conjugate of Poly(ethylene) Glycol and SN38, Administered Weekly in Patients With Advanced Cancer

PURPOSE: This study evaluated the tolerability, pharmacokinetics (PK), and preliminary antitumor activity of EZN-2208, a water-soluble, poly(ethylene) glycol conjugate of SN38. METHODS: Patients with advanced malignancies were enrolled in dose-escalating cohorts (3 + 3 design). EZN-2208 was administ...

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Detalhes bibliográficos
Main Authors: Patnaik, Amita, Papadopoulos, Kyriakos P., Tolcher, Anthony W., Beeram, Muralidhar, Urien, Saïk, Schaaf, Larry J., Tahiri, Sanaa, Bekaii-Saab, Tanios, Lokiec, François M., Rezaï, Keyvan, Buchbinder, Aby
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3839288/
https://ncbi.nlm.nih.gov/pubmed/23543270
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-013-2149-2
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