EZN-2208 treatment suppresses chronic lymphocytic leukaemia by interfering with environmental protection and increases response to fludarabine

The transcription factor HIF-1α is overexpressed in chronic lymphocytic leukaemia (CLL), where it promotes leukaemia progression by favouring the interaction of leukaemic cells with protective tissue microenvironments. Here, we tested the hypothesis that a pharmacological compound previously shown t...

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Publicado en:Open Biol
Autores principales: Valsecchi, Roberta, Coltella, Nadia, Magliulo, Daniela, Bongiovanni, Lucia, Scarfò, Lydia, Ghia, Paolo, Ponzoni, Maurilio, Bernardi, Rosa
Formato: Artigo
Lenguaje:Inglês
Publicado: The Royal Society 2020
Materias:
Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7276525/
https://ncbi.nlm.nih.gov/pubmed/32397871
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1098/rsob.190262
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