Comparison of two self-assembled macromolecular prodrug micelles with different conjugate positions of SN38 for enhancing antitumor activity

7-Ethyl-10-hydroxycamptothecin (SN38), an active metabolite of irinotecan (CPT-11), is a remarkably potent antitumor agent. The clinical application of SN38 has been extremely restricted by its insolubility in water. In this study, we successfully synthesized two macromolecular prodrugs of SN38 with...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Int J Nanomedicine
Egile Nagusiak: Liu, Yi, Piao, Hongyu, Gao, Ying, Xu, Caihong, Tian, Ye, Wang, Lihong, Liu, Jinwen, Tang, Bo, Zou, Meijuan, Cheng, Gang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Dove Medical Press 2015
Gaiak:
Original Research
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376263/
https://ncbi.nlm.nih.gov/pubmed/25848251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/IJN.S77957
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