Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming

BACKGROUND: Exposure to environmental endocrine-disrupting chemicals during pregnancy reportedly causes transgenerationally inherited reproductive defects. We hypothesized that to affect the grandchild, endocrine-disrupting chemicals must alter the epigenome of the germ cells of the in utero-exposed...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Iqbal, Khursheed, Tran, Diana A, Li, Arthur X, Warden, Charles, Bai, Angela Y, Singh, Purnima, Wu, Xiwei, Pfeifer, Gerd P, Szabó, Piroska E
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2015
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376074/
https://ncbi.nlm.nih.gov/pubmed/25853433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0619-z
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