Deleterious effects of endocrine disruptors are corrected in the mammalian germline by epigenome reprogramming

BACKGROUND: Exposure to environmental endocrine-disrupting chemicals during pregnancy reportedly causes transgenerationally inherited reproductive defects. We hypothesized that to affect the grandchild, endocrine-disrupting chemicals must alter the epigenome of the germ cells of the in utero-exposed...

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Détails bibliographiques
Publié dans:Genome Biol
Auteurs principaux: Iqbal, Khursheed, Tran, Diana A, Li, Arthur X, Warden, Charles, Bai, Angela Y, Singh, Purnima, Wu, Xiwei, Pfeifer, Gerd P, Szabó, Piroska E
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2015
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4376074/
https://ncbi.nlm.nih.gov/pubmed/25853433
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-015-0619-z
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