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Properties of an Inward-Facing State of LeuT: Conformational Stability and Substrate Release

The leucine transporter (LeuT) is a bacterial homolog of the human monoamine transporters, which are important pharmaceutical targets. There are no high-resolution structures of the human transporters available; however, LeuT has been crystallized in several different conformational states. Recently...

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Publicat a:Biophys J
Autors principals: Grouleff, Julie, Søndergaard, Siri, Koldsø, Heidi, Schiøtt, Birgit
Format: Artigo
Idioma:Inglês
Publicat: The Biophysical Society 2015
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375683/
https://ncbi.nlm.nih.gov/pubmed/25809252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.02.010
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