Probing the Huntingtin 1-17 Membrane Anchor on a Phospholipid Bilayer by Using All-Atom Simulations

Mislocalization and aggregation of the huntingtin protein are related to Huntington’s disease. Its first exon—more specifically the first 17 amino acids (Htt17)—is crucial for the physiological and pathological functions of huntingtin. It regulates huntingtin’s activity through posttranslational mod...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Biophys J
Prif Awduron: Côté, Sébastien, Binette, Vincent, Salnikov, Evgeniy S., Bechinger, Burkhard, Mousseau, Normand
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Biophysical Society 2015
Pynciau:
Proteins and Nucleic Acids
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375615/
https://ncbi.nlm.nih.gov/pubmed/25762330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.02.001
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