Probing the Huntingtin 1-17 Membrane Anchor on a Phospholipid Bilayer by Using All-Atom Simulations

Mislocalization and aggregation of the huntingtin protein are related to Huntington’s disease. Its first exon—more specifically the first 17 amino acids (Htt17)—is crucial for the physiological and pathological functions of huntingtin. It regulates huntingtin’s activity through posttranslational mod...

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Detalles Bibliográficos
Publicado en:Biophys J
Main Authors: Côté, Sébastien, Binette, Vincent, Salnikov, Evgeniy S., Bechinger, Burkhard, Mousseau, Normand
Formato: Artigo
Idioma:Inglês
Publicado: The Biophysical Society 2015
Assuntos:
Proteins and Nucleic Acids
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375615/
https://ncbi.nlm.nih.gov/pubmed/25762330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.02.001
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