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Free-Energy Landscape of the Amino-Terminal Fragment of Huntingtin in Aqueous Solution
The first exon of Huntingtin—a protein with multiple biological functions whose misfolding is related to Huntington’s disease—modulates its localization, aggregation, and function within the cell. It is composed of a 17-amino-acid amphipathic segment (Htt17), an amyloidogenic segment of consecutive...
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| Pubblicato in: | Biophys J |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Biophysical Society
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4788745/ https://ncbi.nlm.nih.gov/pubmed/26958885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.01.015 |
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