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Free-Energy Landscape of the Amino-Terminal Fragment of Huntingtin in Aqueous Solution
The first exon of Huntingtin—a protein with multiple biological functions whose misfolding is related to Huntington’s disease—modulates its localization, aggregation, and function within the cell. It is composed of a 17-amino-acid amphipathic segment (Htt17), an amyloidogenic segment of consecutive...
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| Publicado no: | Biophys J |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4788745/ https://ncbi.nlm.nih.gov/pubmed/26958885 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2016.01.015 |
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