Probing the Huntingtin 1-17 Membrane Anchor on a Phospholipid Bilayer by Using All-Atom Simulations

Mislocalization and aggregation of the huntingtin protein are related to Huntington’s disease. Its first exon—more specifically the first 17 amino acids (Htt17)—is crucial for the physiological and pathological functions of huntingtin. It regulates huntingtin’s activity through posttranslational mod...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:Biophys J
Main Authors: Côté, Sébastien, Binette, Vincent, Salnikov, Evgeniy S., Bechinger, Burkhard, Mousseau, Normand
Format: Artigo
Jezik:Inglês
Izdano: The Biophysical Society 2015
Teme:
Proteins and Nucleic Acids
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375615/
https://ncbi.nlm.nih.gov/pubmed/25762330
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2015.02.001
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