Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease: Effect of N-acetyl transferase polymorphisms

AIM: To evaluate variation of the concentration of thiopurine metabolites after 5-aminosalicylate (5-ASA) interruption and the role of genetic polymorphisms of N-acetyl transferase (NAT) 1 and 2. METHODS: Concentrations of thioguanine nucleotides (TGN) and methymercaptopurine nucleotides (MMPN), met...

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Vydáno v:World J Gastroenterol
Hlavní autoři: Stocco, Gabriele, Cuzzoni, Eva, De Iudicibus, Sara, Favretto, Diego, Malusà, Noelia, Martelossi, Stefano, Pozzi, Elena, Lionetti, Paolo, Ventura, Alessandro, Decorti, Giuliana
Médium: Artigo
Jazyk:Inglês
Vydáno: Baishideng Publishing Group Inc 2015
Témata:
Retrospective Study
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375579/
https://ncbi.nlm.nih.gov/pubmed/25834322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v21.i12.3571
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