Pharmacogenetics of azathioprine in inflammatory bowel disease: A role for glutathione-S-transferase?

Azathioprine is a purine antimetabolite drug commonly used to treat inflammatory bowel disease (IBD). In vivo it is active after reaction with reduced glutathione (GSH) and conversion to mercaptopurine. Although this reaction may occur spontaneously, the presence of isoforms M and A of the enzyme gl...

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Autors principals: Stocco, Gabriele, Pelin, Marco, Franca, Raffaella, De Iudicibus, Sara, Cuzzoni, Eva, Favretto, Diego, Martelossi, Stefano, Ventura, Alessandro, Decorti, Giuliana
Format: Artigo
Idioma:Inglês
Publicat: Baishideng Publishing Group Co., Limited 2014
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974520/
https://ncbi.nlm.nih.gov/pubmed/24707136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v20.i13.3534
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