Pharmacogenetics of azathioprine in inflammatory bowel disease: A role for glutathione-S-transferase?

Azathioprine is a purine antimetabolite drug commonly used to treat inflammatory bowel disease (IBD). In vivo it is active after reaction with reduced glutathione (GSH) and conversion to mercaptopurine. Although this reaction may occur spontaneously, the presence of isoforms M and A of the enzyme gl...

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Main Authors: Stocco, Gabriele, Pelin, Marco, Franca, Raffaella, De Iudicibus, Sara, Cuzzoni, Eva, Favretto, Diego, Martelossi, Stefano, Ventura, Alessandro, Decorti, Giuliana
Format: Artigo
Language:Inglês
Published: Baishideng Publishing Group Co., Limited 2014
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3974520/
https://ncbi.nlm.nih.gov/pubmed/24707136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3748/wjg.v20.i13.3534
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