Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants

The contribution of candidate genetic variants involved in azathioprine biotransformation on azathioprine efficacy and pharmacokinetics in 111 young patients with inflammatory bowel disease was evaluated. Azathioprine doses, metabolites thioguanine-nucleotides (TGN) and methylmercaptopurine-nucleoti...

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Detalhes bibliográficos
Publicado no:Genes (Basel)
Main Authors: Lucafò, Marianna, Stocco, Gabriele, Martelossi, Stefano, Favretto, Diego, Franca, Raffaella, Malusà, Noelia, Lora, Angela, Bramuzzo, Matteo, Naviglio, Samuele, Cecchin, Erika, Toffoli, Giuseppe, Ventura, Alessandro, Decorti, Giuliana
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523194/
https://ncbi.nlm.nih.gov/pubmed/30987408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes10040277
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