Azathioprine Biotransformation in Young Patients with Inflammatory Bowel Disease: Contribution of Glutathione-S Transferase M1 and A1 Variants

The contribution of candidate genetic variants involved in azathioprine biotransformation on azathioprine efficacy and pharmacokinetics in 111 young patients with inflammatory bowel disease was evaluated. Azathioprine doses, metabolites thioguanine-nucleotides (TGN) and methylmercaptopurine-nucleoti...

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Détails bibliographiques
Publié dans:Genes (Basel)
Auteurs principaux: Lucafò, Marianna, Stocco, Gabriele, Martelossi, Stefano, Favretto, Diego, Franca, Raffaella, Malusà, Noelia, Lora, Angela, Bramuzzo, Matteo, Naviglio, Samuele, Cecchin, Erika, Toffoli, Giuseppe, Ventura, Alessandro, Decorti, Giuliana
Format: Artigo
Langue:Inglês
Publié: MDPI 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6523194/
https://ncbi.nlm.nih.gov/pubmed/30987408
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes10040277
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