Perilipin 5 Regulates Islet Lipid Metabolism and Insulin Secretion in a cAMP-Dependent Manner: Implication of Its Role in the Postprandial Insulin Secretion

Elevation of circulating fatty acids (FA) during fasting supports postprandial (PP) insulin secretion that is critical for glucose homeostasis and is impaired in diabetes. We tested our hypothesis that lipid droplet (LD) protein perilipin 5 (PLIN5) in β-cells aids PP insulin secretion by regulating...

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Dettagli Bibliografici
Pubblicato in:Diabetes
Autori principali: Trevino, Michelle B., Machida, Yui, Hallinger, Daniel R., Garcia, Eden, Christensen, Aaron, Dutta, Sucharita, Peake, David A., Ikeda, Yasuhiro, Imai, Yumi
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Diabetes Association 2015
Soggetti:
Islet Studies
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375085/
https://ncbi.nlm.nih.gov/pubmed/25392244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0559
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