Perilipin 5 Regulates Islet Lipid Metabolism and Insulin Secretion in a cAMP-Dependent Manner: Implication of Its Role in the Postprandial Insulin Secretion

Elevation of circulating fatty acids (FA) during fasting supports postprandial (PP) insulin secretion that is critical for glucose homeostasis and is impaired in diabetes. We tested our hypothesis that lipid droplet (LD) protein perilipin 5 (PLIN5) in β-cells aids PP insulin secretion by regulating...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Trevino, Michelle B., Machida, Yui, Hallinger, Daniel R., Garcia, Eden, Christensen, Aaron, Dutta, Sucharita, Peake, David A., Ikeda, Yasuhiro, Imai, Yumi
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2015
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4375085/
https://ncbi.nlm.nih.gov/pubmed/25392244
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db14-0559
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