Identification of Small Molecules that Disrupt Signaling between ABL and Its Positive Regulator RIN1

Constitutively active BCR-ABL kinase fusions are causative mutations in the pathogenesis of hematopoietic neoplasias including chronic myelogenous leukemia (CML). Although these fusions have been successfully targeted with kinase inhibitors, drug-resistance and relapse continue to limit long-term su...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:PLoS One
मुख्य लेखकों: Ting, Pamela Y., Damoiseaux, Robert, Titz, Björn, Bradley, Kenneth A., Graeber, Thomas G., Fernández-Vega, Virneliz, Bannister, Thomas D., Chase, Peter, Nair, Reji, Scampavia, Louis, Hodder, Peter, Spicer, Timothy P., Colicelli, John
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: Public Library of Science 2015
विषय:
Research Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374917/
https://ncbi.nlm.nih.gov/pubmed/25811598
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0121833
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