RGS1 regulates myeloid cell accumulation in atherosclerosis and aortic aneurysm rupture through altered chemokine signalling

Chemokine signalling drives monocyte recruitment in atherosclerosis and aortic aneurysms. The mechanisms that lead to retention and accumulation of macrophages in the vascular wall remain unclear. Regulator of G-Protein Signalling-1 (RGS1) deactivates G-protein signalling, reducing the response to s...

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Udgivet i:Nat Commun
Main Authors: Patel, Jyoti, McNeill, Eileen, Douglas, Gillian, Hale, Ashley B., de Bono, Joseph, Lee, Regent, Iqbal, Asif J., Regan-Komito, Daniel, Stylianou, Elena, Greaves, David R., Channon, Keith M.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2015
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4374153/
https://ncbi.nlm.nih.gov/pubmed/25782711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms7614
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