Increased Mitochondrial Fission and Volume Density by Blocking Glutamate Excitotoxicity Protect Glaucomatous Optic Nerve Head Astrocytes

Abnormal structure and function of astrocytes have been observed within the lamina cribrosa region of the optic nerve head (ONH) in glaucomatous neurodegeneration. Glutamate excitotoxicity-mediated mitochondrial alteration has been implicated in experimental glaucoma. However, the relationships amon...

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Detalhes bibliográficos
Publicado no:Glia
Main Authors: Ju, Won-Kyu, Kim, Keun-Young, Noh, You Hyun, Hoshijima, Masahiko, Lukas, Thomas J, Ellisman, Mark H, Weinreb, Robert N, Perkins, Guy A
Formato: Artigo
Idioma:Inglês
Publicado em: BlackWell Publishing Ltd 2015
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373968/
https://ncbi.nlm.nih.gov/pubmed/25557093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22781
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