Increased Mitochondrial Fission and Volume Density by Blocking Glutamate Excitotoxicity Protect Glaucomatous Optic Nerve Head Astrocytes

Abnormal structure and function of astrocytes have been observed within the lamina cribrosa region of the optic nerve head (ONH) in glaucomatous neurodegeneration. Glutamate excitotoxicity-mediated mitochondrial alteration has been implicated in experimental glaucoma. However, the relationships amon...

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Bibliographische Detailangaben
Veröffentlicht in:Glia
Hauptverfasser: Ju, Won-Kyu, Kim, Keun-Young, Noh, You Hyun, Hoshijima, Masahiko, Lukas, Thomas J, Ellisman, Mark H, Weinreb, Robert N, Perkins, Guy A
Format: Artigo
Sprache:Inglês
Veröffentlicht: BlackWell Publishing Ltd 2015
Schlagworte:
Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373968/
https://ncbi.nlm.nih.gov/pubmed/25557093
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/glia.22781
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