A new vicious cycle involving glutamate excitotoxicity, oxidative stress and mitochondrial dynamics

Glutamate excitotoxicity leads to fragmented mitochondria in neurodegenerative diseases, mediated by nitric oxide and S-nitrosylation of dynamin-related protein 1, a mitochondrial outer membrane fission protein. Optic atrophy gene 1 (OPA1) is an inner membrane protein important for mitochondrial fus...

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Detalhes bibliográficos
Main Authors: Nguyen, D, Alavi, M V, Kim, K-Y, Kang, T, Scott, R T, Noh, Y H, Lindsey, J D, Wissinger, B, Ellisman, M H, Weinreb, R N, Perkins, G A, Ju, W-K
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252734/
https://ncbi.nlm.nih.gov/pubmed/22158479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2011.117
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