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Wnt3a Protein Reduces Growth Factor-Driven Expansion of Human Hematopoietic Stem and Progenitor Cells in Serum-Free Cultures

Ex vivo expansion of hematopoietic stem and progenitor cells (HSPC) is a promising approach to improve insufficient engraftment after umbilical cord blood stem cell transplantation (UCB-SCT). Although culturing HSPC with hematopoietic cytokines results in robust proliferation, it is accompanied with...

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Τόπος έκδοσης:	PLoS One
Κύριοι συγγραφείς:	Duinhouwer, Lucia E., Tüysüz, Nesrin, Rombouts, Elwin W. J. C., ter Borg, Mariette N. D., Mastrobattista, Enrico, Spanholtz, Jan, Cornelissen, Jan J., ten Berge, Derk, Braakman, Eric
Μορφή:	Artigo
Γλώσσα:	Inglês
Έκδοση:	Public Library of Science 2015
Θέματα:	Research Article
Διαθέσιμο Online:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4373922/ https://ncbi.nlm.nih.gov/pubmed/25807521 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0119086
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Wnt3a Protein Reduces Growth Factor-Driven Expansion of Human Hematopoietic Stem and Progenitor Cells in Serum-Free Cultures

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