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Timp3 Deficient Mice Show Resistance to Developing Breast Cancer

Timp3 is commonly silenced in breast cancer, but mechanistic studies have identified both tumor promotion and suppression effects of this gene. We have taken a genetic approach to determine the impact of Timp3 loss on two mouse models of breast cancer. Interestingly, MMTV-PyMT Timp3(−⁄−) mice have d...

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Pubblicato in:PLoS One
Autori principali: Jackson, Hartland W., Hojilla, Carlo V., Weiss, Ashley, Sanchez, Otto H., Wood, Geoffrey A., Khokha, Rama
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373869/
https://ncbi.nlm.nih.gov/pubmed/25807548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120107
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