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Timp3 Deficient Mice Show Resistance to Developing Breast Cancer

Timp3 is commonly silenced in breast cancer, but mechanistic studies have identified both tumor promotion and suppression effects of this gene. We have taken a genetic approach to determine the impact of Timp3 loss on two mouse models of breast cancer. Interestingly, MMTV-PyMT Timp3(−⁄−) mice have d...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Jackson, Hartland W., Hojilla, Carlo V., Weiss, Ashley, Sanchez, Otto H., Wood, Geoffrey A., Khokha, Rama
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373869/
https://ncbi.nlm.nih.gov/pubmed/25807548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120107
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