Timp3 Deficient Mice Show Resistance to Developing Breast Cancer

Timp3 is commonly silenced in breast cancer, but mechanistic studies have identified both tumor promotion and suppression effects of this gene. We have taken a genetic approach to determine the impact of Timp3 loss on two mouse models of breast cancer. Interestingly, MMTV-PyMT Timp3(−⁄−) mice have d...

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Udgivet i:PLoS One
Main Authors: Jackson, Hartland W., Hojilla, Carlo V., Weiss, Ashley, Sanchez, Otto H., Wood, Geoffrey A., Khokha, Rama
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2015
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373869/
https://ncbi.nlm.nih.gov/pubmed/25807548
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0120107
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