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Regional delivery of mesothelin-targeted CAR T cell therapy generates potent and long-lasting CD4-dependent tumor immunity

Translating the recent success of chimeric antigen receptor (CAR) T cell therapy for hematological malignancies to solid tumors will necessitate overcoming several obstacles, including inefficient T cell tumor infiltration and insufficient functional persistence. Taking advantage of an orthotopic mo...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Sci Transl Med
Asıl Yazarlar: Adusumilli, Prasad S., Cherkassky, Leonid, Villena-Vargas, Jonathan, Colovos, Christos, Servais, Elliot, Plotkin, Jason, Jones, David R., Sadelain, Michel
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2014
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4373413/
https://ncbi.nlm.nih.gov/pubmed/25378643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.3010162
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