Suppression of the Pregnane X Receptor during Endoplasmic Reticulum Stress Is Achieved by Down-Regulating Hepatocyte Nuclear Factor-4α and Up-Regulating Liver-Enriched Inhibitory Protein

Endoplasmic reticulum (ER) stress is recognized as a common theme in the development of metabolic syndrome and other diseases. Chronic liver diseases develop ER stress and also show decreased capacity of drug metabolism. The pregnane X receptor (PXR) is a master regulator of genes involved in drug e...

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Dades bibliogràfiques
Publicat a:Toxicol Sci
Autors principals: Vachirayonsti, Thaveechai, Ho, Karen W., Yang, Dongfang, Yan, Bingfang
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2015
Matèries:
Regulation of Pregnane X Receptor During ER Stress
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372669/
https://ncbi.nlm.nih.gov/pubmed/25616597
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv008
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