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Suppression of the Pregnane X Receptor during Endoplasmic Reticulum Stress Is Achieved by Down-Regulating Hepatocyte Nuclear Factor-4α and Up-Regulating Liver-Enriched Inhibitory Protein
Endoplasmic reticulum (ER) stress is recognized as a common theme in the development of metabolic syndrome and other diseases. Chronic liver diseases develop ER stress and also show decreased capacity of drug metabolism. The pregnane X receptor (PXR) is a master regulator of genes involved in drug e...
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| Foilsithe in: | Toxicol Sci |
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| Main Authors: | , , , |
| Formáid: | Artigo |
| Teanga: | Inglês |
| Foilsithe: |
Oxford University Press
2015
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| Ábhair: | |
| Rochtain Ar Líne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4372669/ https://ncbi.nlm.nih.gov/pubmed/25616597 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfv008 |
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