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MicroRNA-30c-1-3p IS A SILENCER OF THE PREGNANE X RECEPTOR BY TARGETING THE 3’-UNTRANSLATED REGION AND ALTERS THE EXPRESSION OF ITS TARGET GENE CYTOCHROME P450 3A4
The pregnane X receptor (PXR) is a master regulator of genes involved in drug elimination. Recently, activation of PXR has also been linked to the development of many disease conditions such as metabolic disorders and malignancies. MicroRNAs (miRs) emerge as important molecular species involved in t...
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| Publicat a: | Biochim Biophys Acta |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2016
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4975670/ https://ncbi.nlm.nih.gov/pubmed/27085140 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbagrm.2016.03.016 |
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