Pregnane X receptor is required for interleukin-6 mediated down-regulation of cytochrome P450 3A4 in human hepatocytes

Cytochrome P450 3A4 (CYP 3A4) is the most abundant cytochrome P450 enzyme in human liver and metabolizes more than 60% of prescribed drugs in human body. Patients with liver conditions such as cirrhosis show increased secretion of cytokines (e.g, interleukin-6) and decreased capacity of oxidation of...

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Detalhes bibliográficos
Main Authors: Yang, Jian, Hao, Chunshu, Yang, Dongfang, Shi, Deshi, Song, Xiulong, Luan, Xiaofei, Hu, Gang, Yan, Bingfang
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2932899/
https://ncbi.nlm.nih.gov/pubmed/20538049
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.toxlet.2010.06.003
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