Opposite Phenotypes of Muscle Strength and Locomotor Function in Mouse Models of Partial Trisomy and Monosomy 21 for the Proximal Hspa13-App Region

The trisomy of human chromosome 21 (Hsa21), which causes Down syndrome (DS), is the most common viable human aneuploidy. In contrast to trisomy, the complete monosomy (M21) of Hsa21 is lethal, and only partial monosomy or mosaic monosomy of Hsa21 is seen. Both conditions lead to variable physiologic...

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Detalhes bibliográficos
Publicado no:PLoS Genet
Main Authors: Brault, Véronique, Duchon, Arnaud, Romestaing, Caroline, Sahun, Ignasi, Pothion, Stéphanie, Karout, Mona, Borel, Christelle, Dembele, Doulaye, Bizot, Jean-Charles, Messaddeq, Nadia, Sharp, Andrew J., Roussel, Damien, Antonarakis, Stylianos E, Dierssen, Mara, Hérault, Yann
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2015
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372517/
https://ncbi.nlm.nih.gov/pubmed/25803843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005062
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