Opposite Phenotypes of Muscle Strength and Locomotor Function in Mouse Models of Partial Trisomy and Monosomy 21 for the Proximal Hspa13-App Region

The trisomy of human chromosome 21 (Hsa21), which causes Down syndrome (DS), is the most common viable human aneuploidy. In contrast to trisomy, the complete monosomy (M21) of Hsa21 is lethal, and only partial monosomy or mosaic monosomy of Hsa21 is seen. Both conditions lead to variable physiologic...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:PLoS Genet
Prif Awduron: Brault, Véronique, Duchon, Arnaud, Romestaing, Caroline, Sahun, Ignasi, Pothion, Stéphanie, Karout, Mona, Borel, Christelle, Dembele, Doulaye, Bizot, Jean-Charles, Messaddeq, Nadia, Sharp, Andrew J., Roussel, Damien, Antonarakis, Stylianos E, Dierssen, Mara, Hérault, Yann
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Public Library of Science 2015
Pynciau:
Research Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4372517/
https://ncbi.nlm.nih.gov/pubmed/25803843
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pgen.1005062
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