Cognition and Hippocampal Plasticity in the Mouse Is Altered by Monosomy of a Genomic Region Implicated in Down Syndrome

Down syndrome (DS) is due to increased copy number of human chromosome 21. The contribution of different genetic regions has been tested using mouse models. As shown previously, the Abcg1-U2af1 genetic region contributes to cognitive defects in working and short-term recognition memory in Down syndr...

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Detalhes bibliográficos
Main Authors: Sahún, Ignasi, Marechal, Damien, Pereira, Patricia Lopes, Nalesso, Valérie, Gruart, Agnes, Garcia, José Maria Delgado, Antonarakis, Stylianos E., Dierssen, Mara, Herault, Yann
Formato: Artigo
Idioma:Inglês
Publicado em: Genetics Society of America 2014
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Investigations
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4096369/
https://ncbi.nlm.nih.gov/pubmed/24752061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.114.165241
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