KCC2 activity is critical in limiting the onset and severity of status epilepticus

The K(+)/Cl(–) cotransporter (KCC2) allows adult neurons to maintain low intracellular Cl(–) levels, which are a prerequisite for efficient synaptic inhibition upon activation of γ-aminobutyric acid receptors. Deficits in KCC2 activity are implicated in epileptogenesis, but how increased neuronal ac...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:Proc Natl Acad Sci U S A
Hoofdauteurs: Silayeva, Liliya, Deeb, Tarek Z., Hines, Rochelle M., Kelley, Matt R., Munoz, Michaelanne B., Lee, Henry H. C., Brandon, Nicholas J., Dunlop, John, Maguire, Jaime, Davies, Paul A., Moss, Stephen J.
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: National Academy of Sciences 2015
Onderwerpen:
Biological Sciences
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371976/
https://ncbi.nlm.nih.gov/pubmed/25733865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415126112
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!

Gelijkaardige items