KCC2 activity is critical in limiting the onset and severity of status epilepticus

The K(+)/Cl(–) cotransporter (KCC2) allows adult neurons to maintain low intracellular Cl(–) levels, which are a prerequisite for efficient synaptic inhibition upon activation of γ-aminobutyric acid receptors. Deficits in KCC2 activity are implicated in epileptogenesis, but how increased neuronal ac...

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Pubblicato in:Proc Natl Acad Sci U S A
Autori principali: Silayeva, Liliya, Deeb, Tarek Z., Hines, Rochelle M., Kelley, Matt R., Munoz, Michaelanne B., Lee, Henry H. C., Brandon, Nicholas J., Dunlop, John, Maguire, Jaime, Davies, Paul A., Moss, Stephen J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2015
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4371976/
https://ncbi.nlm.nih.gov/pubmed/25733865
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415126112
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