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KCC2 activity is critical in limiting the onset and severity of status epilepticus
The K(+)/Cl(–) cotransporter (KCC2) allows adult neurons to maintain low intracellular Cl(–) levels, which are a prerequisite for efficient synaptic inhibition upon activation of γ-aminobutyric acid receptors. Deficits in KCC2 activity are implicated in epileptogenesis, but how increased neuronal ac...
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Veröffentlicht in: | Proc Natl Acad Sci U S A |
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Hauptverfasser: | , , , , , , , , , , |
Format: | Artigo |
Sprache: | Inglês |
Veröffentlicht: |
National Academy of Sciences
2015
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Schlagworte: | |
Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4371976/ https://ncbi.nlm.nih.gov/pubmed/25733865 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1415126112 |
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